Gene information
Official symbol KNG1
Official full name kininogen 1
Gene type protein-coding gene
Chromosome3q27.3
Alias symbolBK
Previous symbolKNG; BDK
Gene familyCystatins, type 3; Neuropeptides
Resources
Entrez Gene 3827
HGNC HGNC:6383
Ensembl ENSG00000113889
Vega OTTHUMG00000150348
UCSC uc003fqr.4
GO terms: 53 records
GO Description Category LogP Number of genes Detail
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0004857 enzyme inhibitor activity GO Molecular Functions -18.4005452 35 More
GO:0004866 endopeptidase inhibitor activity GO Molecular Functions -20.0646267 27 More
GO:0004869 cysteine-type endopeptidase inhibitor activity GO Molecular Functions -4.04506120 6 More
GO:0005539 glycosaminoglycan binding GO Molecular Functions -36.7680176 44 More
GO:0005788 endoplasmic reticulum lumen GO Cellular Components -47.2996164 57 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0007162 negative regulation of cell adhesion GO Biological Processes -21.5212108 58 More
GO:0007204 positive regulation of cytosolic calcium ion concentration GO Biological Processes -15.6883547 39 More
GO:0007596 blood coagulation GO Biological Processes -44.7281461 45 More
GO:0007599 hemostasis GO Biological Processes -44.1075001 45 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008201 heparin binding GO Molecular Functions -33.5542939 37 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0010466 negative regulation of peptidase activity GO Biological Processes -24.1438543 35 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0010951 negative regulation of endopeptidase activity GO Biological Processes -24.7873219 35 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030193 regulation of blood coagulation GO Biological Processes -37.6853179 30 More
GO:0030195 negative regulation of blood coagulation GO Biological Processes -29.1940441 22 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030414 peptidase inhibitor activity GO Molecular Functions -19.6181890 27 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031091 platelet alpha granule GO Cellular Components -43.3287145 36 More
GO:0031093 platelet alpha granule lumen GO Cellular Components -40.0105787 31 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0045861 negative regulation of proteolysis GO Biological Processes -27.9905009 43 More
GO:0050817 coagulation GO Biological Processes -44.4773041 45 More
GO:0050818 regulation of coagulation GO Biological Processes -40.0839917 32 More
GO:0050819 negative regulation of coagulation GO Biological Processes -31.8350192 24 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0051346 negative regulation of hydrolase activity GO Biological Processes -26.0030636 42 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0061041 regulation of wound healing GO Biological Processes -35.8633788 36 More
GO:0061045 negative regulation of wound healing GO Biological Processes -28.2986689 25 More
GO:0061134 peptidase regulator activity GO Molecular Functions -19.3582235 29 More
GO:0061135 endopeptidase regulator activity GO Molecular Functions -19.1908633 27 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0072562 blood microparticle GO Cellular Components -39.0217600 39 More
GO:1900046 regulation of hemostasis GO Biological Processes -39.0044157 31 More
GO:1900047 negative regulation of hemostasis GO Biological Processes -30.8008788 23 More
GO:1901681 sulfur compound binding GO Molecular Functions -28.2504512 39 More
GO:1903034 regulation of response to wounding GO Biological Processes -34.9293555 38 More
GO:1903035 negative regulation of response to wounding GO Biological Processes -27.3379640 26 More
KEGG pathways: 7 records
KEGG Description Category LogP Number of genes Detail
hsa04071 Sphingolipid signaling pathway KEGG Pathway -4.55426967 9 More
hsa04080 Neuroactive ligand-receptor interaction KEGG Pathway -22.6219922 65 More
hsa04610 Complement and coagulation cascades KEGG Pathway -50.1154932 39 More
hsa04810 Regulation of actin cytoskeleton KEGG Pathway -10.0068804 19 More
hsa05142 Chagas disease KEGG Pathway -21.3868632 23 More
hsa05143 African trypanosomiasis KEGG Pathway -18.5080428 15 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
Drug-Gene interaction
view
Related drugs: 1 record
Drug name Interaction type Source PMID View
avoralstat TTD view
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
kininogen-1 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction La Follette L et al. J Lab Clin Med. 1987
kininogen-1 proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Cubedo J et al. Thromb Haemost. 2013
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